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Effects of alkylation of the C87A/C115A/C174A/M212C mutant on the substrate selectivity profile, overview C88A - mutant displays significant decrease in 1-chloro-2,4-dinitrobenzene activity D141N site-directed mutagenesis of isozyme GST T1-1, the mutant enzyme behaves similarly to the wild-type enzyme, in terms of expression level and specific activity